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Genetic evidence in planar cell polarity signaling pathway in human neural tube defects
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《医学前沿(英文)》 2014年 第8卷 第1期 页码 68-78 doi: 10.1007/s11684-014-0308-4
Neural tube defects (NTDs) are a group of birth anomalies having a profound physical, emotional, and financial effects on families and communities. Their etiology is complex, involving environmental and genetic factors that interact to modulate the incidence and severity of the developing phenotype. The planar cell polarity (PCP) pathway controls the process of convergent extension (CE) during gastrulation and neural tube closure and has been implicated in the pathogenesis of NTDs in animal models and human cohorts. This review summarizes the cumulative results of recent studies on PCP signaling pathway and human NTDs. These results demonstrate that PCP gene alterations contribute to the etiology of human NTDs.
关键词: planar cell polarity neural tube defects rare mutations
《医学前沿(英文)》 页码 1006-1009 doi: 10.1007/s11684-023-1000-3
关键词: family craniofacial microsomia Identification novel mutations
《医学前沿(英文)》 2023年 第17卷 第1期 页码 18-42 doi: 10.1007/s11684-022-0976-4
关键词: non-small cell lung cancer driver mutations treatment strategy resistant mechanism immune-checkpoint inhibitors
Characteristics of compensatory mutations in the
Shengfen Wang, Yang Zhou, Bing Zhao, Xichao Ou, Hui Xia, Yang Zheng, Yuanyuan Song, Qian Cheng, Xinyang Wang, Yanlin Zhao
《医学前沿(英文)》 2020年 第14卷 第1期 页码 51-59 doi: 10.1007/s11684-019-0720-x
关键词: tuberculosis drug resistance compensatory mutations transmission
《环境科学与工程前沿(英文)》 2022年 第16卷 第6期 doi: 10.1007/s11783-021-1513-4
• Season and landform influenced spatiotemporal patterns of abundant and rare taxa.
关键词: Rare taxa Biogeography Community assembly Bacterioplankton The Yangtze River
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《医学前沿(英文)》 2014年 第8卷 第2期 页码 217-226 doi: 10.1007/s11684-014-0326-2
This study was designed to investigate the contribution of miRNA-122-binding site polymorphism at the IL-1A gene and its multiplicative interactions with hepatitis B virus (HBV) mutations in the risk of hepatocellular carcinoma (HCC). A total of 1021 healthy controls, 302 HBV surface antigen (HBsAg) seroclearance subjects, and 2011 HBsAg-positive subjects (including 1021 HCC patients) were enrolled in this study. Quantitative PCR was used to genotype rs3783553. HBV mutations were determined by direct sequencing. Multivariate logistic regression analyses were performed to test the associations of rs3783553, mutations, and their interactions with the risk of HCC. No significant association was found between rs3783553 and the risk of HCC among healthy controls, HBsAg seroclearance subjects, HBsAg-positive subjects without HCC, and all controls. Additionally, rs3783553 was not significantly associated with chronic HBV infection, liver cirrhosis, HBV e antigen seroconversion, abnormal alanine aminotransferase, and high viral load (>104 copies/ml). However, the TTCA insertion allele of rs3783553 was significantly associated with an increased frequency of HBV C7A mutation compared with homozygous TTCA deletion carriers [(del/ins+ ins/ins) vs. del/del, adjusted odds ratio (OR)=1.48, 95% confidence interval (CI)=1.09-2.02, P=0.013]. Multiplicative interaction of rs3783553 with HBV preS deletion significantly reduced the risk of HCC in males, with an adjusted OR of 0.64 (95% CI=0.42-0.98; P=0.041) after age and HBV genotype were adjusted. Although rs3783553 did not significantly affect genetic susceptibility to HBV-related HCC, its variant allele may predispose the host to selecting HBV C7A mutation during evolution and significantly reduce the risk of HCC caused by HBV preS deletion. This study provides an insight into the complex host-virus interaction in HBV-induced hepatocarcinogenesis and is helpful in determining HBsAg-positive subjects who are likely to develop HCC.
关键词: hepatocellular carcinoma (HCC) interaction miRNA-122-binding site IL-1A rs3783553 hepatitis B virus (HBV) mutations
Recovery of rare and precious metals from urban mines—A review
Mengmeng Wang, Quanyin Tan, Joseph F. Chiang, Jinhui Li
《环境科学与工程前沿(英文)》 2017年 第11卷 第5期 doi: 10.1007/s11783-017-0963-1
关键词: Rare and precious metals (RPMs) Distribution characteristics Recycling technology Emerging technology Supercritical fluid
王登红,孙艳,代鸿章,郭唯明,赵芝,赵汀,李建康,王成辉,黄凡,于扬,李德先
《中国工程科学》 2019年 第21卷 第1期 页码 119-127 doi: 10.15302/J-SSCAE-2019.01.017
我国“三稀矿产”总体上资源丰富,既是资源大国,也是主要生产国和出口国,但往往因为深加工技术落后、环境代价太大、战略意识不强等原因而始终拿不到市场的话语权。中国已经进入科技创新引领社会发展的关键时期,“三稀矿产”恰恰具有无限的创新潜力。本文通过梳理2011年以来全国“三稀矿产”资源调查和找矿过程中积累的资料,概略性地总结了我国稀有、稀土和稀散元素矿产的主要特点,提出了一些开发利用建议,进一步强调“稀土不土,稀有常有,稀散不散”的禀赋特征,提出了开发利用过程中“稀土管得着,稀有找得到,稀散用得好”的基本思路。
《环境科学与工程前沿(英文)》 2023年 第17卷 第8期 doi: 10.1007/s11783-023-1702-4
● Column experiments with an inclined slope were applied to simulate NH4–N transport.
关键词: Ion-absorbed rare earth Ammonium nitrogen transport HYDRUS-2D Numerical simulation
Rare tumors: a blue ocean of investigation
《医学前沿(英文)》 2023年 第17卷 第2期 页码 220-230 doi: 10.1007/s11684-023-0984-z
关键词: rare tumors diagnosis flowchart treatment strategy clinical trials recommendation
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《医学前沿(英文)》 2017年 第11卷 第2期 页码 284-286 doi: 10.1007/s11684-017-0514-y
Arsenic trioxide (ATO), a component of the traditional Chinese medicine arsenic sublimate, promotes apoptosis and induces leukemic cell differentiation. Combined with all-trans-retinotic acid (ATRA), ATO has become the first-line induction therapy in treating acute promyelocytic leukemia (APL). The most common side effects of ATO include hepatotoxicity, gastrointestinal symptoms, water-sodium retention, and nervous system damage. In this report, we present a rare side effect, rhabdomyolysis, in a 68-year-old female APL patient who was treated with ATO. After taking 10 mg ATO daily for 6 days, she presented shortness of breath, myodynia, elevated creatine kinase, and acute renal insufficiency. This report describes the first case of ATO-induced rhabdomyolysis.
《医学前沿(英文)》 2022年 第16卷 第4期 页码 627-636 doi: 10.1007/s11684-020-0815-4
关键词: RUNX1 gene mutation acute myeloid leukemia transcriptional repression DNA methylation
Rare-earth separation based on the differences of ionic magnetic moment via quasi-liquid strategy
《化学科学与工程前沿(英文)》 2023年 第17卷 第10期 页码 1584-1594 doi: 10.1007/s11705-022-2189-4
关键词: rare earth element different magnetic moment magnetic separation ionic liquid
Chunfeng Wang, Guanfei Chen, Yanchen Zhu, Dan Yao, Wanfeng Wang, Lianjun Wang
《环境科学与工程前沿(英文)》 2017年 第11卷 第6期 doi: 10.1007/s11783-017-0946-2
关键词: Assessment Rare earth elements Leaching behavior Bioaccessibility Hospital waste
Preparation of rare-earth metal complex oxide catalysts for catalytic wet air oxidation
LI Ning, LI Guangming, YAO Zhenya, ZHAO Jianfu
《环境科学与工程前沿(英文)》 2007年 第1卷 第2期 页码 190-195 doi: 10.1007/s11783-007-0033-1
关键词: torch-atomic emission Brunauer Catalytic process stability
标题 作者 时间 类型 操作
Identification of novel mutations in and in a family with craniofacial microsomia: evidence of digenic
期刊论文
Treatment of advanced non-small cell lung cancer with driver mutations: current applications and future
期刊论文
Characteristics of compensatory mutations in the
Shengfen Wang, Yang Zhou, Bing Zhao, Xichao Ou, Hui Xia, Yang Zheng, Yuanyuan Song, Qian Cheng, Xinyang Wang, Yanlin Zhao
期刊论文
Distinct community assembly processes underlie significant spatiotemporal dynamics of abundant and rare
期刊论文
122-binding site polymorphism at the interleukin-1 α gene and its interaction with hepatitis B virus mutations
null
期刊论文
Recovery of rare and precious metals from urban mines—A review
Mengmeng Wang, Quanyin Tan, Joseph F. Chiang, Jinhui Li
期刊论文
Migration of ammonium nitrogen in ion-absorbed rare earth soils during and post mining: a column study
期刊论文
Arsenic trioxide induced rhabdomyolysis, a rare but severe side effect, in an APL patient: a case report
null
期刊论文
Distinct gene expression pattern of mutations coordinated by target repression and promoter hypermethylation
期刊论文
Rare-earth separation based on the differences of ionic magnetic moment via quasi-liquid strategy
期刊论文
Assessment of leaching behavior and human bioaccessibility of rare earth elements in typical hospital
Chunfeng Wang, Guanfei Chen, Yanchen Zhu, Dan Yao, Wanfeng Wang, Lianjun Wang
期刊论文